Time：2014-8-1 11:19:55　Browse：946次
Myasthenia Gravis is categorized as disease of atrophy in terms of TCM. Based on treatment experiences by doctors of different historical ages, our hospital created originally the “Eight Extra Channels Therapeutic Theory” and applied a series of Zhongjiling preparations and Jiweiling Injection for the MG treatment and gained favorable clinical effect. Some of the patients however, still do not receive notable improvements due to individual differences. In order to promote scientific research level and elevate the therapeutic effect, we used the most advanced bone marrow mesenchymal stem cell transplantation to transplant mesenchymal stem cells into patients of MG for inhibiting T-cell immuno-reactivity through secretion of TGF-β and HGF so as to suppress immunoreactions and start immune reconstruction. Assisted by Zhongjiling prepared by our hospital, the transplantation treatment improves autoimmune function with enhanced effect and reduced symptom recurrence.
Bone marrow mesenchymal stem cells are the progenitor cell of many kinds of mesenchymal cells with the ability of self-differentiation and self-proliferation. Compared with the transplantation of peripheral blood hematopoietic stem cells used by some other hospitals, the differences are:
1. Transplantation of bone marrow mesenchymal stem cells is less painful, less side effect and low infection risk while transplantation of peripheral blood hematopoietic stem cells requires the maximal reduction of lymphcyte through radiotherapy and chemotherapy. The immunosuppressant of chemotherapy may cause loss of hair, liver impairment and other side effects, and the reduction of lymphcyte raises the risk of uncontrollable infection and fever; low level of thrombocyte leads to easily bleeding, Mycoplamal Pneumonia, hemorrhagic cystitis, hepatic veno-occlusive disease and other complications.
2. Transplantation of bone marrow mesenchymal stem cells requires shorter therapeutic period, that is all together 1 week from bone marrow collection to stem cell cultivation, purification and to the transplantation into patient's body while the transplantation of peripheral blood hematopoietic stem cells takes at least 2 weeks from self lymphcyte reduction to stem cell transfusion, and the patients must be kept in asepsis flow laminar wards.
3.Transplantation of bone marrow mesenchymal stem cells costs lower than 10 thousand Yuan, while transplantation of peripheral blood hematopoietic stem cells costs 100~300 thousand Yuan.
4.Transplantation of bone marrow mesenchymal stem cells has good effect on the short run and remarkable amelioration on patient's clinical symptom as eyelid prolapse, limb weakness, heaviness in chest area and short of breath and improvement of patient's Life quality. Therapeutic effect on the long run still calls for further observation.
Under the guideline of scientificness, preciseness, honesty, concretion, safety and efficiency, we introduced the internationally leading bone marrow mesenchymal stem cell transplantation to the vast group of MG patients. We have faith in the active integrated medical treatment assisted by modern high technology therapy to bring hopes to more MG patients. We sincerely hope that all the MG patients come to systematic treatments in time and regain a health life.